PPARα Agonists Reduce Alcohol Drinking: Do They Act in the Brain or in the Liver?
نویسندگان
چکیده
Eduardo Karahanian1,*, Mario Rivera-Meza2, María Elena Quintanilla2, Daniel Muñoz1, Katia Fernández3, and Yedy Israel2 Center for Biomedical Research, Faculty of Health Sciences, Universidad Autónoma de Chile, Santiago, Chile, Program of Molecular and Clinical Pharmacology, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Santiago, Chile, and Faculty of Health and Dentistry, Universidad Diego Portales, Santiago, Chile
منابع مشابه
Letter to the Editor PPARα Agonists Reduce Alcohol Drinking: Do They Act in the Brain or in the Liver?
Eduardo Karahanian1,*, Mario Rivera-Meza2, María Elena Quintanilla2, Daniel Muñoz1, Katia Fernández3, and Yedy Israel2 Center for Biomedical Research, Faculty of Health Sciences, Universidad Autónoma de Chile, Santiago, Chile, Program of Molecular and Clinical Pharmacology, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Santiago, Chile, and Faculty of Health and De...
متن کاملPPAR agonists regulate brain gene expression: relationship to their effects on ethanol consumption.
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that act as ligand-activated transcription factors. Although prescribed for dyslipidemia and type-II diabetes, PPAR agonists also possess anti-addictive characteristics. PPAR agonists decrease ethanol consumption and reduce withdrawal severity and susceptibility to stress-induced relapse in rodents. However, the c...
متن کاملAlcoholism – the Worst Addiction
Introduction: The most common substance of abuse/dependence in patients presenting for treatment in western countries is alcohol. Ethyl alcohol or ethanol which is also called medicinal alcohol is used as an official drug compendium. It is also administered as an antidote in methanol poisoning. However, regular consumption of high amounts of alcoholic drinks induces dependence and addiction lea...
متن کاملP 95: Result of Alcohol Excessive Drinking in the Brain and Varying Mental Health Side Effects
Alcohol directly affects astroglial cell function, including inflammation-related activity. And it also affects microglial cell development and function in specific ways that interfere with microglial interactions with the immune system and with neurons. Neuroinflammatory processes might be involved in alcohol-induced brain damage. Alcohol use, misuse and getting used to it causes differe...
متن کاملPeroxisome proliferator-activated receptors α and γ are linked with alcohol consumption in mice and withdrawal and dependence in humans.
BACKGROUND Peroxisome proliferator-activated receptor (PPAR) agonists reduce voluntary ethanol (EtOH) consumption in rat models and are promising therapeutics in the treatment for drug addictions. We studied the effects of different classes of PPAR agonists on chronic EtOH intake and preference in mice with a genetic predisposition for high alcohol consumption and then examined human genomewide...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Alcohol and alcoholism
دوره 50 6 شماره
صفحات -
تاریخ انتشار 2015